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Thiourea Tyrosinase Inhibition

Inhibitory effect of thiourea on tyrosinase

It is a matter of the world, and the biochemical reason is subtle. Tyrosinase has a crucial role in the color change of organisms and other things. Now on the inhibition of thiourea on tyrosinase, the wonderful truth should be studied carefully.

Thiourea has a unique nature. When encountering tyrosinase, the two interact, just like yin and yang sympathetic, then sympathetic, not to promote its activity, but to inhibit it. Looking at the mechanism of its action, thiourea is combined with the check point of tyrosinase activity with its molecular structure. This combination, such as the interlocking of mortise and tenon, changes the conformation of the active center of the enzyme, which is like a slight flaw in beautiful jade, resulting in the loss of its catalytic energy.

Try to verify it. In the various reaction systems, different amounts of thiourea are added, while the amount of tyrosinase is constant with the substrate. After time inspection, it is seen that with the increase of thiourea, the rate of tyrosinase catalyzing the substrate gradually slows down. This change is not accidental, but is actually a manifestation of the inhibition of tyrosinase by thiourea.

And explore the wide range of its effects. In the biological world, tyrosinase is related to the formation of pigments. If thiourea exerts its inhibition ability, it may change the color of organisms. For example, some fruits and vegetables are prone to browning after harvest, due to the oxidation of tyrosinase-stimulated substrates. If thiourea is added, or it can delay its browning, it will keep its color delicious, which is of great benefit to food preservation.

Furthermore, in the field of medicine, there are also considerations. Tyrosinase is abnormally active, or it can cause melanoma and other diseases. The inhibition of thiourea, or to explore the path of treatment, should be carefully studied.

In short, the inhibition of thiourea on tyrosinase is profound and widely used. In scientific research, production, and medicine, it has the value of inquiry. We should use scientific methods to dig deep into its mysteries and seek for the well-being of mankind.